Hāʻawi ke kūlohelohe i nā pōpoki me ke ʻano o ke kaulike kupaianaha, e ʻae iā lākou e hele ma nā ʻoka, nā lālā lāʻau me ka dexterity o kahi mea hele wāwae paʻa maoli, e piʻi, e peʻe ana mai ko lākou mau ʻenemi, i nā wahi manaʻo ʻole ʻia loa. ʻO ke ʻano o ke kaulike a me ka hoʻonohonoho maikaʻi ʻana o ka neʻe ʻana e lele loa ai nā pōpoki. Hiki i ka pōpoki maʻamau ke lele ma mua o ʻelima mau manawa kona kiʻekiʻe ponoʻī.
He aha ka mea e hoʻoholo ai i ka hiki i nā pōpoki ke mālama i ke ʻano o ke kaulike a me ka hoʻohui ʻana o ka neʻe ʻana i kēlā me kēia kūlana. I nā felines, e like me nā mammal āpau, kahi ʻokoʻa o ka lolo, ka cerebellum, ke kuleana no ka hoʻohui ʻana i ka neʻe. ʻO ka ʻikepili mai ka honua a puni e hele mai ma o ka cerebellum, ua kālailai ʻia a lawe ʻia ma o ke kaulahao i ka mīkini kaʻa. Aia ka paʻakikī o ka ʻōnaehana kaʻa o ke kino i ka nui o ka cerebellum. I nā pōpoki, ʻo ka nui o kēia ʻāpana o ka lolo ma kahi o 100 cm2, e ʻae ai iā mākou e kamaʻilio e pili ana i kahi hoʻomohala maikaʻi o ka cerebellum, a ʻo kēia, kahi ʻōnaehana paʻakikī a kaulike maikaʻi o ka hoʻonohonoho a me ke kaulike.
Ma waho o ka lolo, ke kaulike maikaʻi ma muli o ka mākala a me ka iwi o nā pōpoki. Hoʻokomo ʻia kēlā me kēia mākala me nā mea loaʻa he nui i hoʻouna ʻia a laila loaʻa nā ʻike kūpono mai ka lolo. ʻOkoʻa ke ʻano iwi o ka pōpoki i ka ʻokoʻa ma mua o nā mammals ʻē aʻe. Ua ʻike ka hapa nui i ka maʻalahi o kā mākou mau holoholona. Pili kēia mau mea āpau i ka pili o ka iwi kuamoo i kekahi i kekahi me ka hoʻohana ʻana i nā mākala, ma mua o nā ligament a me nā aʻa. ʻAe kēia ʻano i nā pōpoki e pelu a wili i nā ʻano maʻamau ʻole.
Pono e hoʻomaopopo ʻia he mea kōkua waiwai hou aʻe i ka mālama ʻana i ke kaulike a me ke kaulike ʻana i ka neʻe ʻana he mau mea loaʻa ma nā pale o nā wāwae. ʻAe kēia i ka pōpoki e loiloi i ka hiki ke hala i kekahi a i ʻole nā mea keʻakeʻa.
Mahalo i nā hiʻohiʻona āpau i luna, hiki i nā pōpoki ke neʻe a puni nā wahi noʻonoʻo ʻole, pae mau i nā ʻeke ʻehā (e nānā ʻole mākou i nā ʻano laha o nā pōpoki pākahi, e like me ka ragdoll), noho palekana a kani maikaʻi ke hāʻule mai kahi kiʻekiʻe kiʻekiʻe.